monoclonal gammopathy of undetermined significance with metastatic carcinoma – a rare presentation

Monoclonal Gammopathy of Undetermined Significance with Metastatic Carcinoma – A Rare Presentation

The presence of a low level of M protein in the peripheral blood <3gm/dl which is below the required cut off for the diagnosis of plasma cell myeloma is known as monoclonal gammopathy of undetermined significance (MGUS). Elevated levels of serum M protein and detection of M band on serum protein electrophoresis (SPE) can occur in chronic diseases not related to B cell disorders and not always d...

Monoclonal gammopathy of undetermined significance.

Monoclonal gammopathy of undetermined significance.

Monoclonal gammopathy of undetermined significance is not a benign condition. There is a significant increase in mortality associated with the risk of development of multiple myeloma and related disorders.

Monoclonal Gammopathy of Undetermined Significance

Monoclonal gammopathies are a heterogeneous group of disorders characterized by the stable or progressive proliferation of an abnormal clone of plasma cells that continue pro‐ ducing antibodies [4]. But because these immunoglobulin proteins are abnormal and mon‐ oclonal (identical copies of each other), these offer no protection against infections and can damage the kidney. This monoclonal immu...

Monoclonal gammopathy of undetermined significance.

The condition, also known as benign monoclonal gammopathy, is characterized by the presence of a monoclonal immunoglobulin or light chain on im munofixation of the patient’s serum or urine. Such a diagnosis can only be considered if underlying causes, most notably multiple myeloma, are excluded (Appendix 1, available at www .cmaj .ca /lookup /suppl /doi:10.1503 /cmaj .122090 //DC1). Because mon...

Monoclonal Gammopathy of Undetermined Significance

RESULTS: Of the 359 patients, 330 had nonevolving MGUS, whereas 29 fulfilled the criteria for evolving MGUS. Overall, 32 patients developed malignant transformation. The progression rates at 10 and 20 years of follow-up for the evolving and the nonevolving types were 55% vs 10% and 80% vs 13%, respectively. Multivariate analysis revealed that the features significantly associated with a higher ...